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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbk1M1Btlr
mutation 1, Bruce Beutler
MGI:5442100
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbk1M1Btlr/Tbk1M1Btlr involves: C57BL/6J MGI:5442119
ht2
 		Tbk1M1Btlr/Tbk1+ involves: C57BL/6J MGI:5442118


Genotype
MGI:5442119
hm1
Allelic
Composition		 Tbk1M1Btlr/Tbk1M1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1M1Btlr mutation (1 available); any Tbk1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5442118
ht2
Allelic
Composition		 Tbk1M1Btlr/Tbk1+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1M1Btlr mutation (1 available); any Tbk1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:188770 )
• isolated peritoneal macrophages produce reduced amounts of type I interferon (IFN) in response to transfection with dsDNA oligonucleotides
abnormal interferon secretion ( J:188770 )
• isolated peritoneal macrophages produce reduced amounts of type I interferon (IFN) in response to transfection with dsDNA oligonucleotides

hematopoietic system
abnormal macrophage physiology ( J:188770 )
• isolated peritoneal macrophages produce reduced amounts of type I interferon (IFN) in response to transfection with dsDNA oligonucleotides




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory