Phenotypes associated with this allele

• Allele Symbol: Pax7^{tm1.1(rtTA)Sjl}
• Allele Name: targeted mutation 1.1, Se-Jin Lee
• Allele ID: MGI:5441709
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax7^tm1.1(rtTA)Sjl/Pax7^tm1.1(rtTA)Sjl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5441731
cx2	Pax7^tm1.1(rtTA)Sjl/Pax7^tm1.1(rtTA)Sjl Tg(Myl1-FST)F66Sjl/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5441732

Genotype
MGI:5441731

hm1

• Allelic Composition: Pax7^{tm1.1(rtTA)Sjl}/Pax7^{tm1.1(rtTA)Sjl}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:188599 )

muscle

decreased skeletal muscle weight ( J:188599 )

• in the pectoralis, triceps, quadriceps and gastrocnemius

growth/size/body

decreased body size ( J:188599 )

cachexia ( J:188599 )

• severe wasting

Genotype
MGI:5441732

cx2

• Allelic Composition: Pax7^{tm1.1(rtTA)Sjl}/Pax7^{tm1.1(rtTA)Sjl}; Tg(Myl1-FST)F66Sjl/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

muscle

abnormal skeletal muscle fiber size ( J:188599 )

• shift towards increased fiber size compared with Pax7^{tm3.1(rtTA)Fan} homozygotes

increased skeletal muscle weight ( J:188599 )

• in the pectoralis, triceps, quadriceps and gastrocnemius compared with Pax7^{tm3.1(rtTA)Fan} homozygotes