Pax7^{tm1.1(rtTA)Sjl}
Targeted Allele Detail

Summary

• Symbol: Pax7^{tm1.1(rtTA)Sjl}
• Name: paired box 7; targeted mutation 1.1, Se-Jin Lee
• MGI ID: MGI:5441709
• Gene: Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
• Alliance: Pax7^{tm1.1(rtTA)Sjl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188599
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter, Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region was replaced with a tetracycline transactivator (rtTA), IRES, EGFP, polyadenylation sequence and floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:188599)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax7 Mutation: 39 strains or lines available

References

• Original: J:188599 Lee SJ, et al., Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2353-60
• All: 1 reference(s)