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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lamp5+
wild type
MGI:5441338
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Lamp5em1Lmit/Lamp5+ C57BL/6-Lamp5em1Lmit MGI:7608057
cx2
Lamp5em1Lmit/Lamp5+
Tg(Thy1-APP)3Somm/0
involves: C57BL/6 * C57BL/6J * DBA/2 MGI:7608059


Genotype
MGI:7608057
ht1
Allelic
Composition
Lamp5em1Lmit/Lamp5+
Genetic
Background
C57BL/6-Lamp5em1Lmit
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamp5em1Lmit mutation (0 available); any Lamp5 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit an increase in severity and reduced latency of pentylenetetrazole-induced excitotoxic seizure than in wild-type mice
• mice show delayed habituation in the open field task
• however, no hyperactivity is seen

nervous system
• mice exhibit an increase in severity and reduced latency of pentylenetetrazole-induced excitotoxic seizure than in wild-type mice

mortality/aging
N
• mice exhibit normal survival




Genotype
MGI:7608059
cx2
Allelic
Composition
Lamp5em1Lmit/Lamp5+
Tg(Thy1-APP)3Somm/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamp5em1Lmit mutation (0 available); any Lamp5 mutation (28 available)
Tg(Thy1-APP)3Somm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival is reduced similarly to that seen in single Tg(Thy1-APP)3Somm hemizygotes until 150 days and thereafter shows a trend towards increased mortality

behavior/neurological
• learning in the Morris water maze is impaired compared to single Tg(Thy1-APP)3Somm hemizygotes at 12 months of age
• memory formation in the Morris water maze is impaired compared to single Tg(Thy1-APP)3Somm hemizygotes at 12 months of age

homeostasis/metabolism
• amyloid beta formation and plaque load in aged mice is similar to single Tg(Thy1-APP)3Somm hemizygotes

nervous system
• amyloid beta formation and plaque load in aged mice is similar to single Tg(Thy1-APP)3Somm hemizygotes
• spectral power at gamma (30-100 Hz) frequency is increased more than in single Tg(Thy1-APP)3Somm hemizygotes, indicating neuronal network hypersynchronicity
• theta/gamma cross frequency coupling, an EEG measure linked to memory, is disrupted more than in single Tg(Thy1-APP)3Somm hemizygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory