Lamp5^em1Lmit
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lamp5^em1Lmit
• Name: lysosomal-associated membrane protein family, member 5; endonuclease-mediated mutation 1, Lars M Ittner
• MGI ID: MGI:7608054
• Synonyms: Lamp5^delta
• Gene: Lamp5 Location: Chr2:135894159-135911837 bp, + strand Genetic Position: Chr2, 67.26 cM, cytoband G1
• Alliance: Lamp5^em1Lmit page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 250 bp deletion comprising the transcriptional start in exon 1. (J:345459)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamp5 Mutation: 28 strains or lines available

References

• Original: J:345459 Deng Y, et al., Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease. Acta Neuropathol. 2022 Oct;144(4):637-650
• All: 1 reference(s)