Phenotypes associated with this allele

• Allele Symbol: Slc3a2^tm1.1Yait
• Allele Name: targeted mutation 1.1, Yasuhiko Ito
• Allele ID: MGI:5440713
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc3a2^tm1.1Yait/Slc3a2^tm1.1Yait Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6NCrSlc	MGI:5440716

Genotype
MGI:5440716

cn1

• Allelic Composition: Slc3a2^tm1.1Yait/Slc3a2^tm1.1Yait; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage morphology ( J:188365 )

• round-shaped in vitro macrophage

abnormal macrophage differentiation ( J:188365 )

• impaired formation of multinucleated giant-cell formation from peritoneal macrophages

abnormal macrophage physiology ( J:188365 )

• macrophages induce less T cell proliferation compared with control cells

• however, low spreading activity is normal

impaired macrophage phagocytosis ( J:188365 )

abnormal macrophage antigen presentation ( J:188365 )

• reduced antigen presenting activity

cellular

abnormal macrophage differentiation ( J:188365 )

• impaired formation of multinucleated giant-cell formation from peritoneal macrophages

impaired macrophage phagocytosis ( J:188365 )

hematopoietic system

abnormal macrophage morphology ( J:188365 )

• round-shaped in vitro macrophage

abnormal macrophage differentiation ( J:188365 )

• impaired formation of multinucleated giant-cell formation from peritoneal macrophages

abnormal macrophage physiology ( J:188365 )

• macrophages induce less T cell proliferation compared with control cells

• however, low spreading activity is normal

impaired macrophage phagocytosis ( J:188365 )

abnormal macrophage antigen presentation ( J:188365 )

• reduced antigen presenting activity