Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem}
• Allele Name: targeted mutation 1.1, Rolf Kemler
• Allele ID: MGI:5440174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^tm1.1(Ctnnb1)Kem Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA	MGI:5440177

Genotype
MGI:5440177

cn1

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem}; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal germ layer development ( J:187739 )

• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium

failure to gastrulate ( J:187739 )

• expression analysis indicates failure to gastrulate

abnormal embryonic tissue morphology ( J:187739 )

• formation of proper embryonic structures is incomplete