All Phenotypes Braf<tm2Cpri> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Braf^tm2Cpri/Braf⁺	involves: C57BL/6	MGI:5440070
cn2	Braf^tm2Cpri/Braf⁺ Tg(CMV-cre)1Cgn/0	B6.Cg-Braf^tm2Cpri Tg(CMV-cre)1Cgn	MGI:5440072
cn3	Braf^tm2Cpri/Braf⁺ Kras^tm4Tyj/Kras⁺	involves: 129S4/SvJae * C57BL/6	MGI:5440071

Allelic Composition	Braf^tm2Cpri/Braf⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm2Cpri mutation (0 available); any Braf mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:187371 )

N	• mouse embryonic fibroblast treated with adenoviral-cre exhibit normal growth rate

respiratory system

respiratory system phenotype ( J:187371 )

N	• mice treated intranasally with adenovirus-cre do not exhibit lung abnormalities

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:187371 )

• only 70% of mice survive to adulthood with some mice lost after weaning

cardiovascular system

increased myocardial fiber size ( J:187371 )

thick interventricular septum ( J:187371 )

enlarged heart ( J:187371 )

cardiac hypertrophy ( J:187371 )

thick ventricular wall ( J:187371 )

immune system

enlarged spleen ( J:187371 )

• in most mice

increased spleen weight ( J:187371 )

• 4-fold in most mice

lymphoid hyperplasia ( J:187371 )

• one mouse exhibits hyperplasia of lymphoid tissue at 73 weeks

neoplasm

increased intestinal adenoma incidence ( J:187371 )

• one mouse exhibits small intestinal adenoma at 79 weeks

increased skin papilloma incidence ( J:187371 )

• predisposition in aged mice

vision/eye

abnormal eye morphology ( J:187371 )

• including cataracts and watery eyes in some mice

cataract ( J:187371 )

• in some mice

craniofacial

abnormal facial morphology ( J:187371 )

• facial dysmorphia

long incisors ( J:187371 )

• in some mice

growth/size/body

enlarged heart ( J:187371 )

cardiac hypertrophy ( J:187371 )

abnormal facial morphology ( J:187371 )

• facial dysmorphia

long incisors ( J:187371 )

• in some mice

decreased body weight ( J:187371 )

decreased body height ( J:187371 )

enlarged spleen ( J:187371 )

• in most mice

increased spleen weight ( J:187371 )

• 4-fold in most mice

muscle

increased myocardial fiber size ( J:187371 )

nervous system

increased susceptibility to ischemic brain injury ( J:187371 )

• in some mice

reproductive system

abnormal myometrium morphology ( J:187371 )

• one mouse exhibits hyperplasia of the smooth muscles of the uterus at 23 weeks

uterus prolapse ( J:187371 )

• in some mice

digestive/alimentary system

intestine polyps ( J:187371 )

• predisposition in aged mice

increased intestinal adenoma incidence ( J:187371 )

• one mouse exhibits small intestinal adenoma at 79 weeks

hematopoietic system

enlarged spleen ( J:187371 )

• in most mice

increased spleen weight ( J:187371 )

• 4-fold in most mice

integument

increased skin papilloma incidence ( J:187371 )

• predisposition in aged mice

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:187371 )

• in some mice

skeleton

long incisors ( J:187371 )

• in some mice

Allelic Composition	Braf^tm2Cpri/Braf⁺ Kras^tm4Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm2Cpri mutation (0 available); any Braf mutation (58 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased fibroblast proliferation ( J:187371 )

• in primary mouse embryonic fibroblasts treated with adenovirus-cre compared with wild-type cells although not as much as in cells heterozygous for Kras^tm4Tyj

neoplasm

increased lung adenoma incidence ( J:187371 )

• in mice infected with adenovirus cre

• however, mice do not exhibit increased lung tumor incidence compared with Kras^tm4Tyj heterozygotes

respiratory system

increased lung adenoma incidence ( J:187371 )

• in mice infected with adenovirus cre

• however, mice do not exhibit increased lung tumor incidence compared with Kras^tm4Tyj heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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