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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Heg1tm2.1Mlkn
targeted mutation 2.1, Mark L Kahn
MGI:5439491
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:5439509
cn2
 		Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2tm1Mlkn/Ccm2+
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:5439515


Genotype
MGI:5439509
cn1
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Heg1tm2.1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

muscle




Genotype
MGI:5439515
cn2
Allelic
Composition		 Ccm2ltm1Mlkn/Ccm2ltm1Mlkn
Ccm2tm1Mlkn/Ccm2+
Heg1tm1Mlkn/Heg1tm2.1Mlkn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2ltm1Mlkn mutation (0 available); any Ccm2l mutation (14 available)
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (47 available)
Heg1tm1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Heg1tm2.1Mlkn mutation (0 available); any Heg1 mutation (56 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:187714 )
• some survivors are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory