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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Znrf3tm1Cle
targeted mutation 1, Hans Clevers
MGI:5439366
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd MGI:5439368
cn2
 		Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Tg(Vil1-cre/ERT2)23Syr/0 		involves: C57BL/6 * DBA/2 MGI:5439367


Genotype
MGI:5439368
cn1
Allelic
Composition		 Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
Rnf43tm1Cle mutation (0 available); any Rnf43 mutation (37 available)
Znrf3tm1Cle mutation (0 available); any Znrf3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:186765 )
• form after tamoxifen treatment and contain Olfm4+ stem cells and Paneth cells

digestive/alimentary system
increased intestinal adenoma incidence ( J:186765 )
• form after tamoxifen treatment and contain Olfm4+ stem cells and Paneth cells




Genotype
MGI:5439367
cn2
Allelic
Composition		 Rnf43tm1Cle/Rnf43tm1Cle
Znrf3tm1Cle/Znrf3tm1Cle
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf43tm1Cle mutation (0 available); any Rnf43 mutation (37 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
Znrf3tm1Cle mutation (0 available); any Znrf3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:186765 )
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen
abnormal small intestine crypts of Lieberkuhn morphology ( J:186765 )
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen with enlarged crypts and Ki67+ cells ectopically located on the flanks of villi
• increase in the number of Olfm4+ stem cells after tamoxifen treatment
increased Paneth cell number ( J:186765 )
• increased number after tamoxifen treatment
increased intestinal adenoma incidence ( J:186765 )
• form within 1 month of clonal deletion induced by low dose tamoxifen treatment
• contain Olfm4+ stem cells and Paneth cells

neoplasm
increased intestinal adenoma incidence ( J:186765 )
• form within 1 month of clonal deletion induced by low dose tamoxifen treatment
• contain Olfm4+ stem cells and Paneth cells

cellular
abnormal small intestinal crypt cell proliferation ( J:186765 )
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:186765 )
• following tamoxifen treatment a marked expansion of the proliferative compartment is seen with enlarged crypts and Ki67+ cells ectopically located on the flanks of villi
• increase in the number of Olfm4+ stem cells after tamoxifen treatment
increased Paneth cell number ( J:186765 )
• increased number after tamoxifen treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory