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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cbx5tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5438242
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cbx5tm1.1Ics/Cbx5tm1.1Ics involves: 129S2/SvPas * C57BL/6 MGI:5438247


Genotype
MGI:5438247
hm1
Allelic
Composition		 Cbx5tm1.1Ics/Cbx5tm1.1Ics
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbx5tm1.1Ics mutation (0 available); any Cbx5 mutation (415 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:186702 )
N
• mice exhibit normal lymphoid development
abnormal T-helper 2 physiology ( J:186702 )
• TH2 cells exhibit increased plasticity under TH1 promoting conditions compared with wild-type cells

hematopoietic system
abnormal T-helper 2 physiology ( J:186702 )
• TH2 cells exhibit increased plasticity under TH1 promoting conditions compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory