Cbx5^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Cbx5^tm1.1Ics
• Name: chromobox 5; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5438242
• Synonyms: HP1alpha^-
• Gene: Cbx5 Location: Chr15:103099971-103148243 bp, - strand Genetic Position: Chr15, 58.34 cM
• Alliance: Cbx5^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186702
• Parent Cell Line: MCI (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of intron 4. Cre-mediated recombination removed exon 3, exon 4 and the neo cassette. (J:186702)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbx5 Mutation: 412 strains or lines available

References

• Original: J:186702 Allan RS, et al., An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature. 2012 Jul 12;487(7406):249-53
• All: 2 reference(s)