Analysis Tools
mortality/aging
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• most mice die before the first year of age
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nervous system
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• adrenal medulla chromaffin cells exhibit decreased intracellular ATP compared with wild-type cells
• mice exhibit a decrease in catecholaminergic cells compared with wild-type mice
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• exhibit impaired maturation and accelerated degeneration of dopaminergic cells, aggressively in the substantia nigra pars compacta, compared with wild-type mice
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• mice exhibit decreased neuron numbers in the adrenal medulla, carotid body and superior cervical ganglion compared with wild-type mice
• mice exhibit a decrease in catecholaminergic cells compared with wild-type mice
• progressive reduction in the ventral mesencephalic TH+ neurons with almost complete disappearance of neurons between 6 and 12 months
• neurons loss is less severe in the ventral tegmental area
• however, treatment with an antioxidant in the drinking water rescues neuron survival
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behavior/neurological
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• progressive bradykinetic syndrome with decreased distance traveled in the open field and increase in time spent at rest
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bradykinesia
(
J:186713
)
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• progressive bradykinetic syndrome with decreased distance traveled in the open field and increase in time spent at rest
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endocrine/exocrine glands
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• adrenal medulla chromaffin cells exhibit decreased intracellular ATP compared with wild-type cells
• mice exhibit a decrease in catecholaminergic cells compared with wild-type mice
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homeostasis/metabolism
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• at 2.5 months, mice fail to exhibit an increase in dopamine and its metabolites unlike in wild-type mice
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cellular
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• increased lipid peroxidation in the adrenal medulla
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growth/size/body
neoplasm
