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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Havcr1tm1Kuch
targeted mutation 1, Vijay K Kuchroo
MGI:5437711
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Havcr1tm1Kuch/Havcr1tm1Kuch B6.Cg-Havcr1tm1Kuch MGI:5437712
cx2
 		Faslpr/Faslpr
Havcr1tm1Kuch/Havcr1tm1Kuch 		B6.Cg-Havcr1tm1Kuch Faslpr MGI:5437713


Genotype
MGI:5437712
hm1
Allelic
Composition		 Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic
Background		 B6.Cg-Havcr1tm1Kuch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Havcr1tm1Kuch mutation (0 available); any Havcr1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:186484 )
• in many mice over 18 months of age
abnormal T cell differentiation ( J:186484 )
• in mice over 18 months of age almost all T cells are CD44hi
increased double-negative T cell number ( J:186484 )
• increase in CD3+CD4-CD8- cells in mice over 18 months of age
increased CD4-positive, alpha-beta T cell number ( J:186484 )
• increase in the frequency and number of IFNG+ CD4+ cells in older mice
increased CD8-positive, alpha-beta T cell number ( J:186484 )
• increase in the frequency and number of IFNG+ CD8+ cells in older mice
increased activated T cell number ( J:186484 )
• increase in the percentage and number of activated T cells at 10-12 months of age
abnormal B cell physiology ( J:186484 )
• impaired IL10 production by B-regs that becomes more severe with age
abnormal CD4-positive, alpha-beta T cell physiology ( J:186484 )
• cells from old mice produce higher IL10 amounts
abnormal dendritic cell physiology ( J:186484 )
• in culture dendritic cells slightly increase T cell proliferation
autoimmune response ( J:186484 )
• show signs of autoimmunity with age

hematopoietic system
enlarged spleen ( J:186484 )
• in many mice over 18 months of age
abnormal T cell differentiation ( J:186484 )
• in mice over 18 months of age almost all T cells are CD44hi
increased double-negative T cell number ( J:186484 )
• increase in CD3+CD4-CD8- cells in mice over 18 months of age
increased CD4-positive, alpha-beta T cell number ( J:186484 )
• increase in the frequency and number of IFNG+ CD4+ cells in older mice
increased CD8-positive, alpha-beta T cell number ( J:186484 )
• increase in the frequency and number of IFNG+ CD8+ cells in older mice
increased activated T cell number ( J:186484 )
• increase in the percentage and number of activated T cells at 10-12 months of age
abnormal B cell physiology ( J:186484 )
• impaired IL10 production by B-regs that becomes more severe with age
abnormal CD4-positive, alpha-beta T cell physiology ( J:186484 )
• cells from old mice produce higher IL10 amounts

growth/size/body
enlarged spleen ( J:186484 )
• in many mice over 18 months of age




Genotype
MGI:5437713
cx2
Allelic
Composition		 Faslpr/Faslpr
Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic
Background		 B6.Cg-Havcr1tm1Kuch Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Havcr1tm1Kuch mutation (0 available); any Havcr1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:186484 )
• more severe in mice over 10 months of age compared to mice homozygous for Faslpr alone
increased B cell number ( J:186484 )
• massive accumulation of B cells
increased T cell number ( J:186484 )
• increase in the number of B220+CD3+ T cells in the peripheral lymphoid compartments compared to mice homozygous for Faslpr alone
increased double-negative T cell number ( J:186484 )
• massive increase in CD3+B220-CD4-CD8- and CD3+B220+CD4-CD8- T cells
increased CD4-positive, alpha-beta T cell number ( J:186484 )
• massive increase in the accumulation of CD3+B220- CD4+ T cells
• increase in the frequency of IFNG+ cells
increased CD8-positive, alpha-beta T cell number ( J:186484 )
• massive increase in the accumulation of CD3+B220- CD8+ T cells
• increase in the frequency of IFNG+ cells
increased activated T cell number ( J:186484 )
• most T cells have an activated/memory like phenotype
abnormal immunoglobulin level ( J:186484 )
• unlike IgG levels, IgM levels are decreased compared to mice homozygous for Faslpr alone
increased IgG1 level ( J:186484 )
• compared to mice homozygous for Faslpr alone
increased IgG2a level ( J:186484 )
• compared to mice homozygous for Faslpr alone
increased IgG2b level ( J:186484 )
• compared to mice homozygous for Faslpr alone
increased IgG3 level ( J:186484 )
• compared to mice homozygous for Faslpr alone
enlarged lymph nodes ( J:186484 )
• more severe in mice over 10 months of age compared to mice homozygous for Faslpr alone
increased susceptibility to systemic lupus erythematosus ( J:186484 )
• more severe autoimmune response compared to mice homozygous for Faslpr alone
increased autoantibody level ( J:186484 )
• serum levels of some autoantibodies to lupus associated autoantigens are increased at 14 weeks of age in double mutant mice but not in mice homozygous for Faslpr alone
• autoantibodies can be detected as early as 10 weeks of age
increased anti-double stranded DNA antibody level ( J:186484 )
• compared to mice homozygous for Faslpr alone

hematopoietic system
enlarged spleen ( J:186484 )
• more severe in mice over 10 months of age compared to mice homozygous for Faslpr alone
increased B cell number ( J:186484 )
• massive accumulation of B cells
increased T cell number ( J:186484 )
• increase in the number of B220+CD3+ T cells in the peripheral lymphoid compartments compared to mice homozygous for Faslpr alone
increased double-negative T cell number ( J:186484 )
• massive increase in CD3+B220-CD4-CD8- and CD3+B220+CD4-CD8- T cells
increased CD4-positive, alpha-beta T cell number ( J:186484 )
• massive increase in the accumulation of CD3+B220- CD4+ T cells
• increase in the frequency of IFNG+ cells
increased CD8-positive, alpha-beta T cell number ( J:186484 )
• massive increase in the accumulation of CD3+B220- CD8+ T cells
• increase in the frequency of IFNG+ cells
increased activated T cell number ( J:186484 )
• most T cells have an activated/memory like phenotype
abnormal immunoglobulin level ( J:186484 )
• unlike IgG levels, IgM levels are decreased compared to mice homozygous for Faslpr alone
increased IgG1 level ( J:186484 )
• compared to mice homozygous for Faslpr alone
increased IgG2a level ( J:186484 )
• compared to mice homozygous for Faslpr alone
increased IgG2b level ( J:186484 )
• compared to mice homozygous for Faslpr alone
increased IgG3 level ( J:186484 )
• compared to mice homozygous for Faslpr alone

growth/size/body
enlarged spleen ( J:186484 )
• more severe in mice over 10 months of age compared to mice homozygous for Faslpr alone




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory