Phenotypes associated with this allele

• Allele Symbol: Arl6ip5^tm1.2Jwzh
• Allele Name: targeted mutation 1.2, Jianwei Zhou
• Allele ID: MGI:5437298
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arl6ip5^tm1.2Jwzh/Arl6ip5^tm1.2Jwzh	B6.129X1-Arl6ip5^tm1.2Jwzh	MGI:5437304

Genotype
MGI:5437304

hm1

• Allelic Composition: Arl6ip5^tm1.2Jwzh/Arl6ip5^tm1.2Jwzh
• Genetic Background: B6.129X1-Arl6ip5^tm1.2Jwzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Arl6ip5^tm1.2Jwzh/Arl6ip5^tm1.2Jwzh mice show decreased susceptiblity to DMBA/TPA-induced tumor formation

neoplasm

neoplasm ( J:187133 )

N • mice do not exhibit spontaneous tumors

decreased incidence of tumors by chemical induction ( J:187133 )

• DMBA/TPA-treated mice develop fewer and smaller skin papillomas compared with control mice

decreased tumor growth/size ( J:187133 )

• DMBA/TPA-treated mice develop fewer and smaller skin papillomas due to reduced proliferation compared with control mice

skeleton

kyphosis ( J:187133 )

osteoporosis ( J:187133 )

integument

abnormal keratinocyte physiology ( J:187133 )

• keratinocytes exhibit enhanced DMBA-induced DNA damage compared with control cells

growth/size/body

decreased body weight ( J:187133 )

immune system

abnormal immune system organ morphology ( J:187133 )

• immune organ atrophy

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:187133 )

• DMBA/TPA-treated mice develop fewer and smaller skin papillomas compared with control mice