Arl6ip5^tm1.2Jwzh
Targeted Allele Detail

Summary

• Symbol: Arl6ip5^tm1.2Jwzh
• Name: ADP-ribosylation factor-like 6 interacting protein 5; targeted mutation 1.2, Jianwei Zhou
• MGI ID: MGI:5437298
• Synonyms: JWA^delta2
• Gene: Arl6ip5 Location: Chr6:97187753-97210276 bp, + strand Genetic Position: Chr6, 44.91 cM, cytoband D3
• Alliance: Arl6ip5^tm1.2Jwzh page

Arl6ip5^tm1.2Jwzh/Arl6ip5^tm1.2Jwzh mice show decreased susceptiblity to DMBA/TPA-induced tumor formation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187133
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination of Arl6ip5^tm1.1 removed exon 2. Westen blot analysis confirmed the absence of protein expression in the skin. (J:187133)

Generation of the Arl6ip5^tm1.1Jwzh and Arl6ip5^tm1.2Jwzh alleles

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arl6ip5 Mutation: 16 strains or lines available

References

• Original: J:187133 Gong Z, et al., JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice. PLoS One. 2012;7(3):e34154
• All: 3 reference(s)