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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc3a2tm1.1Merl
targeted mutation 1.1, Didier Merlin
MGI:5433604
Summary 2 genotypes


Genotype
MGI:5433666
cn1
Allelic
Composition		 Slc3a2tm1.1Merl/Slc3a2tm1.1Merl
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Slc3a2tm1.1Merl Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc3a2tm1.1Merl mutation (1 available); any Slc3a2 mutation (37 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:173946 )
• fewer than expected mice are born indicating embryonic of neonatal lethality




Genotype
MGI:5433667
cn2
Allelic
Composition		 Slc3a2tm1.1Merl/Slc3a2+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Slc3a2tm1.1Merl Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc3a2tm1.1Merl mutation (1 available); any Slc3a2 mutation (37 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Slc3a2tm1.1Merl/Slc3a2+ Tg(Vil1-cre)997Gum/0 mice are protected from dextran sodium sulfate-induced colitis

mortality/aging
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:173946 )
• in mice treated with azoxymethane and DSS

digestive/alimentary system
abnormal enterocyte proliferation ( J:173946 )
• mice treated with azoxymethane and DSS exhibit reduced colonic epithelial cell proliferation compared with control mice
decreased susceptibility to induced colitis ( J:173946 )
• DSS-treated mice exhibit reduced weight loss, decreased rectal bleeding, no diarrhea, reduced colon shortening, reduced crypt damage and fewer inflammatory infiltrates and ulcerations compared with control mice

neoplasm
decreased incidence of tumors by chemical induction ( J:173946 )
• mice treated with azoxymethane and DSS exhibit fewer and smaller adenomas than in control mice
decreased tumor growth/size ( J:173946 )
• in mice treated with azoxymethane and DSS

growth/size/body
decreased susceptibility to weight loss ( J:173946 )
• in DSS-treated mice or treated with azoxymethane and DSS

homeostasis/metabolism
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:173946 )
• in mice treated with azoxymethane and DSS
decreased incidence of tumors by chemical induction ( J:173946 )
• mice treated with azoxymethane and DSS exhibit fewer and smaller adenomas than in control mice

immune system
decreased susceptibility to induced colitis ( J:173946 )
• DSS-treated mice exhibit reduced weight loss, decreased rectal bleeding, no diarrhea, reduced colon shortening, reduced crypt damage and fewer inflammatory infiltrates and ulcerations compared with control mice

cellular
abnormal enterocyte proliferation ( J:173946 )
• mice treated with azoxymethane and DSS exhibit reduced colonic epithelial cell proliferation compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory