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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chn2tm2.1Alk
targeted mutation 2.1, Alex L Kolodkin
MGI:5433304
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chn2tm2.1Alk/Chn2tm2.1Alk B6.Cg-Chn2tm2.1Alk MGI:5433308
cx2
 		Chn2tm2.1Alk/Chn2+
Nrp2Gt(GST039)Byg/Nrp2+ 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N MGI:5433309


Genotype
MGI:5433308
hm1
Allelic
Composition		 Chn2tm2.1Alk/Chn2tm2.1Alk
Genetic
Background		 B6.Cg-Chn2tm2.1Alk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn2tm2.1Alk mutation (0 available); any Chn2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:186252 )
• infrapyramidal tract neurons exhibit hyperactive pruning compared with wild-type cells
abnormal hippocampus development ( J:186252 )
• at P28, the infrapyramidal tract is shorted than in wild-type mice
• however, the tract at P15 is normal in length

cellular
abnormal axon pruning ( J:186252 )
• infrapyramidal tract neurons exhibit hyperactive pruning compared with wild-type cells




Genotype
MGI:5433309
cx2
Allelic
Composition		 Chn2tm2.1Alk/Chn2+
Nrp2Gt(GST039)Byg/Nrp2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn2tm2.1Alk mutation (0 available); any Chn2 mutation (48 available)
Nrp2Gt(GST039)Byg mutation (1 available); any Nrp2 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus development ( J:186252 )
• at P45, the infrapyramidal tract is longer than in wild-type mice or single heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory