Nrp2^{Gt(GST039)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Nrp2^{Gt(GST039)Byg}
• Name: neuropilin 2; gene trap GST039, BayGenomics
• MGI ID: MGI:1927804
• Synonyms: GST39, neuropilin-2^-, Nrp2^{Gt(pGT1.8TM)39Wcs}
• Gene: Nrp2 Location: Chr1:62742476-62857851 bp, + strand Genetic Position: Chr1, 31.35 cM, cytoband C2
• Alliance: Nrp2^{Gt(GST039)Byg} page

Mutation origin

• Mutant Cell Line: GST039
• Germline Transmission: Earliest citation of germline transmission: J:60158
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1.8TM
• Mutation details: The insertion of the pGT1.8TM secretory trap vector, containing a beta galactosidase reporter gene, occurred in an intron interrupting the neuropilin-2 coding sequence at cDNA position 2069 nt (amino acid Pro-680). The insertion site is located one-third of the way into the MAM domain of neuropilin-2. This mutation appears to be a loss of function. (J:60158)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  GST039	CC156458 ; (MGI Seq Detail)	5' RACE	Chr1:62810922-62810998 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrp2 Mutation: 88 strains or lines available

References

• Original: J:60158 Chen H, et al., Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron. 2000 Jan;25(1):43-56
• All: 10 reference(s)