Analysis Tools
vision/eye
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• animals much thinner optic nerves relative to controls
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• in some animals, severe pathfinding defects are observed as the optic nerve exits the retina, forming a knot-like structure
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• cell death is increased relative to Atoh7-null homozygotes with most dying cells observed in the ganglion cell layer (GCL)
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• the transgenic Crx-Atoh7 (Math5) construct shows variable rescue of retinal axons and prevention of fasciculation defects in double mutants compared to Atoh7-null homozygotes
• rescue is less pronounced with successive generations
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nervous system
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• animals much thinner optic nerves relative to controls
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• in some animals, severe pathfinding defects are observed as the optic nerve exits the retina, forming a knot-like structure
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