Tg(Crx-Atoh7,-cre)251Gla
Transgene Detail

Summary

• Symbol: Tg(Crx-Atoh7,-cre)251Gla
• Name: transgene insertion 251, Tom Glaser
• MGI ID: MGI:5433215
• Synonyms: Crx>Math5 Tg (line 251)
• Transgene: Tg(Crx-Atoh7,-cre)251Gla Location: unknown
• Alliance: Tg(Crx-Atoh7,-cre)251Gla page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2 or (B6;129-Gt(ROSA)26Sor^tm1Sho/J x (C57BL/6 x SJL)F1)

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Crx-Atoh7,-cre)251Gla expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Crx (MGI:1194883)

• Mutation details: The Atoh7 (Math5) and cre recombinase cDNAs, separated by an internal ribosomal entry site (IRES) and followed by an SV40 polyadenylation sequence, were cloned into a plasmid upstream of a 2.4 kb fragment of the mouse Crx gene that contained the promoter and proximal regulatory region. The linearized purified transgene was injected into fertilized oocytes. 2 founders and 2 lines were obtained, crossed to GFP reporter mice and analyzed for GFP and cre expression. A representative line, 251, was chosen for further analysis. (J:186563)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crx (mouse) Summary of all recombinase alleles driven by Crx. Alliance mouse Crx gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186563 Prasov L, et al., Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol. 2012 Aug 15;368(2):214-30
• All: 2 reference(s)