Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation
(1 available);
any
Cdkl5 mutation
(19 available)
Tg(Emx1-cre)#Ito mutation
(0 available)
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behavior/neurological
 N |
• mice exhibit normal activity levels and a trend for decreased head tracking
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation
(1 available);
any
Cdkl5 mutation
(19 available)
Tg(Emx1-cre)#Ito mutation
(0 available)
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behavior/neurological
 N |
• mice exhibit normal activity levels and a trend for decreased head tracking
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1.1Nses mutation
(1 available);
any
Fezf2 mutation
(49 available)
Tbr1tm1Jlr mutation
(1 available);
any
Tbr1 mutation
(38 available)
Tg(Emx1-cre)#Ito mutation
(0 available)
Tg(Mbp-MAPT/EGFP)#Eja mutation
(0 available)
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Aberrant L6 projections to the brainstem in the Tbr1tm1Jlr/Tbr1tm1Jlr mice require Fezf2
nervous system
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• unlike Tbr1tm1Jlr homozygotes, mice lack retrograde labeling of L5 and L6 projection neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1.1Nses mutation
(1 available);
any
Fezf2 mutation
(49 available)
Tg(CAG-cat,-EGFP)39Miya mutation
(1 available)
Tg(Emx1-cre)#Ito mutation
(0 available)
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nervous system
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• mice lack corticospinal axons in the brainstem
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marchf5tm1.1Ygi mutation
(0 available);
any
Marchf5 mutation
(18 available)
Tg(Emx1-cre)#Ito mutation
(0 available)
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behavior/neurological
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• mice show reduced alternation in the Y-maze at P21 and 3 months, suggesting poor short-term memory
• however, mice show normal behavior in the elevated plus maze
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• mice spend less time grooming at P21
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• mice exhibit increased immobility time in the open field test at P21
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cellular
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• neuronal mitochondrial volume and branch number are reduced in the cell body of neurons
• mitochondrial abnormalities are seen with higher frequency in small mitochondria than large mitochondria
• cardiolipin is reduced in mitochondria isolated from brains, however no differences are seen for other phospholipids
• however, mitochondrial swelling is absent and enhanced autophagy or mitophagy is not seen
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• neuronal mitochondria shows numerous dilated, swollen cristae
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• neuronal mitochondria shows empty matrices
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• small and simple structured mitochondria are dominant in neurons, while large branched mitochondria are scarcely detected
• small mitochondria are also seen in astrocytes
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• level of oxidized proteins is enhanced in the hippocampus indicating enhanced oxidative stress in neurons
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hematopoietic system
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• mice show enhanced microglial activation in the cerebral cortex and hippocampus
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homeostasis/metabolism
immune system
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• mice show enhanced microglial activation in the cerebral cortex and hippocampus
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nervous system
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• mice show enhanced microglial activation in the cerebral cortex and hippocampus
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• mice show enhanced astrogliosis in the cerebral cortex and hippocampus
• treatment with a radical scavenger Edaravone attenuates astrogliosis
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• increase in small mitochondria in neurons and loss of large and branched mitochondria
• neurons show reduced endoplasmic reticulum (ER)-mitochondria contact sites; reduction in both total area and the number of ER-mitochondria contact sites and the frequency of ER-mitochondria contact, indicating reduced ER tethering to mitochondria
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agap3tm1Ygi mutation
(0 available);
any
Agap3 mutation
(38 available)
Tg(Emx1-cre)#Ito mutation
(0 available)
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nervous system
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• immature dentate gyrus with decreased mature neuron numbers
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• decreased mature neurons in the dentate gyrus
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behavior/neurological
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• at P21 and 8 weeks without increased anxiety
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Analysis Tools