Marchf5^tm1.1Ygi
Targeted Allele Detail

Summary

• Symbol: Marchf5^tm1.1Ygi
• Name: membrane associated ring-CH-type finger 5; targeted mutation 1.1, Shigeru Yanagi
• MGI ID: MGI:6406741
• Synonyms: MITOL-flox
• Gene: Marchf5 Location: Chr19:37184942-37199550 bp, + strand Genetic Position: Chr19, 32.2 cM
• Alliance: Marchf5^tm1.1Ygi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284572
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked neomycin selection cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neomycin gene, leaving exon 2 floxed. (J:284572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marchf5 Mutation: 18 strains or lines available

References

• Original: J:284572 Nagashima S, et al., MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress. Life Sci Alliance. 2019 Aug;2(4)
• All: 5 reference(s)