All Phenotypes Tg(Ins1-Kcnj11*)#Nich MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Ins1-Kcnj11*)#Nich
transgene insertion, Colin G Nichols
MGI:5432220

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Kcnj11^tm1Sse/Kcnj11⁺ Tg(Ins1-Kcnj11*)#Nich/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5432921
cx2	Kcnj11^tm1Sse/Kcnj11^tm1Sse Tg(Ins1-Kcnj11*)#Nich/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5432923
tg3	Tg(Ins1-Kcnj11*)#Nich/?	B6.Cg-Tg(Ins1-Kcnj11*)#Nich	MGI:5432924

Allelic Composition	Kcnj11^tm1Sse/Kcnj11⁺ Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11^tm1Sse mutation (1 available); any Kcnj11 mutation (31 available)
Tg(Ins1-Kcnj11*)#Nich mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:94610 )

• reduced glucose stimulated insulin on a high fat diet

increased insulin secretion ( J:94610 )

• elevated glucose stimulated insulin secretion at 4 months of age

increased circulating glucose level ( J:94610 )

• higher blood glucose on a high fat diet

increased circulating insulin level ( J:94610 )

• elevated plasma insulin relative to controls on a normal diet but not on a high fat diet

impaired glucose tolerance ( J:94610 )

• glucose intolerant on a high fat diet

improved glucose tolerance ( J:94610 )

• enhanced glucose tolerance at 4 months of age

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:94610 )

• higher insulin content in islets on a normal diet

• normal insulin content in islets on a high fat diet

decreased insulin secretion ( J:94610 )

• reduced glucose stimulated insulin on a high fat diet

increased insulin secretion ( J:94610 )

• elevated glucose stimulated insulin secretion at 4 months of age

Allelic Composition	Kcnj11^tm1Sse/Kcnj11^tm1Sse Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj11^tm1Sse mutation (1 available); any Kcnj11 mutation (31 available)
Tg(Ins1-Kcnj11*)#Nich mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:94610 )

N	• plasma insulin is not elevated on a high fat diet

decreased insulin secretion ( J:94610 )

• reduced baseline insulin secretion but normal plasma insulin

increased circulating glucose level ( J:94610 )

• on a normal diet

• significantly increased blood glucose on a high fat diet relative to controls

impaired glucose tolerance ( J:94610 )

• decreased glucose tolerance on both normal and high fat diet

endocrine/exocrine glands

decreased insulin secretion ( J:94610 )

• reduced baseline insulin secretion but normal plasma insulin

Allelic Composition	Tg(Ins1-Kcnj11*)#Nich/?
Genetic Background	B6.Cg-Tg(Ins1-Kcnj11*)#Nich

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:94610 )

• mice hypersecrete insulin as adults

endocrine/exocrine glands

increased insulin secretion ( J:94610 )

• mice hypersecrete insulin as adults

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