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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gucy1b1tm1.2Frb
targeted mutation 1.2, Andreas Friebe
MGI:5432118
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb
X/Tg(Myh11-icre/ERT2)1Soff
B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-icre/ERT2)1Soff MGI:5432120


Genotype
MGI:5432120
cn1
Allelic
Composition
Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb
X/Tg(Myh11-icre/ERT2)1Soff
Genetic
Background
B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-icre/ERT2)1Soff
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b1tm1.2Frb mutation (0 available); any Gucy1b1 mutation (42 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after more than 50 days of tamoxifen treatment, mice treated with L-NAME fail to exhibit an increase in systolic blood pressure compared with wild-type mice
• in tamoxifen-treated mice
• after more than 50 days of tamoxifen treatment, mice lose aortic relaxation induced by NO, carbachol or sildenafil unlike control mice
• however, mice exhibit normal relaxation in response to 8-Br-cGMP or atrial natriuretic peptide

muscle
• after more than 50 days of tamoxifen treatment, mice lose aortic relaxation induced by NO, carbachol or sildenafil unlike control mice
• however, mice exhibit normal relaxation in response to 8-Br-cGMP or atrial natriuretic peptide





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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory