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Gucy1b1tm1.2Frb
Targeted Allele Detail
Summary
Symbol: Gucy1b1tm1.2Frb
Name: guanylate cyclase 1, soluble, beta 1; targeted mutation 1.2, Andreas Friebe
MGI ID: MGI:5432118
Synonyms: beta1flox
Gene: Gucy1b1  Location: Chr3:81939313-81981996 bp, - strand  Genetic Position: Chr3, 35.97 cM
Alliance: Gucy1b1tm1.2Frb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121321
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 10. A floxed neo cassette was inserted downstream of exon 10. Cre mediated recombination removed the neo cassette and left exon 10 floxed. (J:121321)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gucy1b1 Mutation:  42 strains or lines available
References
Original:  J:121321 Friebe A, et al., Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7699-704
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory