Phenotypes associated with this allele

• Allele Symbol: Cntf^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5432014
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cntf^tm1Vlcg/Cntf^tm1Vlcg	B6.Cg-Cntf^tm1Vlcg	MGI:5432020
hm2	Cntf^tm1Vlcg/Cntf^tm1Vlcg	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5432789

Genotype
MGI:5432020

hm1

• Allelic Composition: Cntf^tm1Vlcg/Cntf^tm1Vlcg
• Genetic Background: B6.Cg-Cntf^tm1Vlcg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:185957 )

• increased following middle cerebral artery occlusion

increased cerebral infarct size ( J:185957 )

• following middle cerebral artery occlusion

homeostasis/metabolism

increased cerebral infarct size ( J:185957 )

• following middle cerebral artery occlusion

cellular

astrocytosis ( J:185957 )

• increased following middle cerebral artery occlusion

Genotype
MGI:5432789

hm2

• Allelic Composition: Cntf^tm1Vlcg/Cntf^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

nervous system

nervous system phenotype ( J:186611 )

N • neuron migration in the rostral migratory stream is normal

abnormal neuron proliferation ( J:186611 )

• adult neuron proliferation in the subventricular zone nuclei is reduced compared to in wild-type mice

• after quipirole or 6-OHDA treatment, adult neuron proliferation in the subventricular zone nuclei is not alter unlike in wild-type mice

decreased neuronal precursor cell number ( J:186611 )

• in the subventricular zone nuclei of quinpirole-treated mice

cellular

abnormal neuron proliferation ( J:186611 )

• adult neuron proliferation in the subventricular zone nuclei is reduced compared to in wild-type mice

• after quipirole or 6-OHDA treatment, adult neuron proliferation in the subventricular zone nuclei is not alter unlike in wild-type mice