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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cntftm1Vlcg
targeted mutation 1, Velocigene
MGI:5432014
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cntftm1Vlcg/Cntftm1Vlcg B6.Cg-Cntftm1Vlcg MGI:5432020
hm2
 		Cntftm1Vlcg/Cntftm1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac MGI:5432789


Genotype
MGI:5432020
hm1
Allelic
Composition		 Cntftm1Vlcg/Cntftm1Vlcg
Genetic
Background		 B6.Cg-Cntftm1Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntftm1Vlcg mutation (0 available); any Cntf mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
astrocytosis ( J:185957 )
• increased following middle cerebral artery occlusion
increased cerebral infarct size ( J:185957 )
• following middle cerebral artery occlusion

homeostasis/metabolism
increased cerebral infarct size ( J:185957 )
• following middle cerebral artery occlusion

cellular
astrocytosis ( J:185957 )
• increased following middle cerebral artery occlusion




Genotype
MGI:5432789
hm2
Allelic
Composition		 Cntftm1Vlcg/Cntftm1Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntftm1Vlcg mutation (0 available); any Cntf mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:186611 )
N
• neuron migration in the rostral migratory stream is normal
abnormal neuron proliferation ( J:186611 )
• adult neuron proliferation in the subventricular zone nuclei is reduced compared to in wild-type mice
• after quipirole or 6-OHDA treatment, adult neuron proliferation in the subventricular zone nuclei is not alter unlike in wild-type mice
decreased neuronal precursor cell number ( J:186611 )
• in the subventricular zone nuclei of quinpirole-treated mice

cellular
abnormal neuron proliferation ( J:186611 )
• adult neuron proliferation in the subventricular zone nuclei is reduced compared to in wild-type mice
• after quipirole or 6-OHDA treatment, adult neuron proliferation in the subventricular zone nuclei is not alter unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory