All Phenotypes Tert<tm3Rdp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tert^tm3Rdp/Tert^tm3Rdp	involves: C57BL/6	MGI:5431981
cn2	Pten^tm1Rdp/Pten^tm1Rdp Tert^tm3Rdp/Tert^tm3Rdp Trp53^tm1Brn/Trp53^tm1Brn Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5431978

Allelic Composition	Tert^tm3Rdp/Tert^tm3Rdp
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tert^tm3Rdp mutation (0 available); any Tert mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased apoptosis ( J:186105 )

• in highly proliferative tissues in late generation mice

increased small intestinal crypt cell apoptosis ( J:186105 )

• in late generation mice

decreased cell proliferation ( J:186105 )

• in highly proliferative tissues in late generation mice

growth/size/body

decreased body weight ( J:186105 )

• in late generation mice

reproductive system

decreased testis weight ( J:186105 )

• in late generation mice

testicular atrophy ( J:186105 )

• in late generation mice

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:186105 )

• in late generation mice

endocrine/exocrine glands

decreased testis weight ( J:186105 )

• in late generation mice

testicular atrophy ( J:186105 )

• in late generation mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:186105 )

• develop bulky lethal tumors by age 24 weeks of age

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:186105 )

• at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age

increased prostate intraepithelial neoplasia incidence ( J:186105 )

• at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

neoplasm

increased prostate gland adenocarcinoma incidence ( J:186105 )

• at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age

increased prostate intraepithelial neoplasia incidence ( J:186105 )

• at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

increased metastatic potential ( J:186105 )

• in some (5 of 20) G3/4 mice lumbar spine metastases are seen unlike in G0 mice

reproductive system

increased prostate gland adenocarcinoma incidence ( J:186105 )

• at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age

increased prostate intraepithelial neoplasia incidence ( J:186105 )

• at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

cellular

abnormal chromosome morphology ( J:186105 )

• increase in the number of chromosomal aberrations in tumor cells from G3/4 mice compared to G0 mice

increased telomere length ( J:186105 )

• increased length in prostate tumor cells compared to G3/4 mice homozygous for Tert^tm1Rdp, Pten^tm1Rdp and Trp53^tm1Brn and hemizygous for Tg(Pbsn-cre)4Prb

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:186105

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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