Phenotypes associated with this allele

• Allele Symbol: Apc^tm1.1Klne
• Allele Name: targeted mutation 1.1, Kristi L Neufeld
• Allele ID: MGI:5431889
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apc^tm1.1Klne/Apc^tm1.1Klne	B6.129-Apc^tm1.1Klne	MGI:5431899
ht2	Apc^Min/Apc^tm1.1Klne	B6.Cg-Apc^Min/Apc^tm1.1Klne	MGI:5431900

Genotype
MGI:5431899

hm1

• Allelic Composition: Apc^tm1.1Klne/Apc^tm1.1Klne
• Genetic Background: B6.129-Apc^tm1.1Klne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal enterocyte proliferation ( J:186132 )

• increased in crypts from jejunum, ileum and colon

colon polyps ( J:186132 )

• in one mouse

gastric polyps ( J:186132 )

• in one mouse

cellular

abnormal enterocyte proliferation ( J:186132 )

• increased in crypts from jejunum, ileum and colon

Genotype
MGI:5431900

ht2

• Allelic Composition: Apc^Min/Apc^tm1.1Klne
• Genetic Background: B6.Cg-Apc^Min/Apc^tm1.1Klne

digestive/alimentary system

abnormal enterocyte proliferation ( J:186132 )

• increased compared with Apc^Min heterozygotes

intestine polyps ( J:186132 )

• mice develop more polyps in the jejunum, ileum, duodenum and stomach compared with Apc^Min heterozygotes

• mice exhibit larger polyps in the jejunum and ileum compared with Apc^Min heterozygotes

• however, the number of polyps in the colon is the same as in Apc^Min heterozygotes

cellular

abnormal enterocyte proliferation ( J:186132 )

• increased compared with Apc^Min heterozygotes