Phenotypes associated with this allele

• Allele Symbol: Trp53^tm2.1Wgu
• Allele Name: targeted mutation 2.1, Wei Gu
• Allele ID: MGI:5431730
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2.1Wgu/Trp53^tm2.1Wgu	involves: 129S6/SvEvTac * C57BL/6	MGI:5431826

Genotype
MGI:5431826

hm1

• Allelic Composition: Trp53^tm2.1Wgu/Trp53^tm2.1Wgu
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:186159 )

N • MEFs exhibit normal glucose uptake, glycolysis and reactive oxygen species

abnormal cell cycle ( J:186159 )

• irradiated mouse embryonic fibroblasts exhibit defective cell cycle arrest compared with wild-type cells

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated

increased fibroblast proliferation ( J:186159 )

• in mouse embryonic fibroblasts

delayed cellular replicative senescence ( J:186159 )

• in mouse embryonic fibroblasts

neoplasm

neoplasm ( J:186159 )

N • mice exhibit normal spontaneous tumors development

immune system

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated

hematopoietic system

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:186159 )

• gamma-irradiation-induced apoptosis is virtually abrogated