All Phenotypes Arhgap33<tm1.1Wbm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgap33^tm1.1Wbm/Arhgap33^tm1.1Wbm	Not Specified	MGI:5431234
cn2	Arhgap33^tm1.1Wbm/Arhgap33^tm1.1Wbm Cdc42^tm1Brak/Cdc42⁺ Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5431235

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain size ( J:185948 )

• small reduction in total brain volume

abnormal cerebral cortex morphology ( J:185948 )

• decrease in total cortical volume

• however, cell number and distribution are similar to wild-type controls

abnormal neocortex morphology ( J:185948 )

• thinner in the parietal, somatosensory and auditory regions at 5 days of age

abnormal visual cortex morphology ( J:185948 )

• thin

thin cerebral cortex ( J:185948 )

• in dorsal and dorsolateral cortical areas, including the secondary motor, somatosensory, parietal, retrosplenial granular and visual and auditory cortex

abnormal parietal lobe morphology ( J:185948 )

• thin parietal cortex

abnormal somatosensory cortex morphology ( J:185948 )

• thin

abnormal auditory cortex morphology ( J:185948 )

• thin

abnormal neuron morphology ( J:185948 )

• cortical neurons show extensive formation of actin-rich lamellipodia and filopodia in culture

abnormal dendrite morphology ( J:185948 )

• strong reduction in the dendritic complexity but no difference is seen in the number of primary dendrites in layer II/III pyramidal neurons but not in layer V neurons

Allelic Composition	Arhgap33^tm1.1Wbm/Arhgap33^tm1.1Wbm Cdc42^tm1Brak/Cdc42⁺ Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap33^tm1.1Wbm mutation (0 available); any Arhgap33 mutation (45 available)
Cdc42^tm1Brak mutation (0 available); any Cdc42 mutation (43 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal parietal lobe morphology ( J:185948 )

• significant improvement in parietal cortical thickness compared to mice homozygous for Arhgap33^tm1.1Wbm alone

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