Phenotypes associated with this allele

• Allele Symbol: Ptbp2^tm1.1Rbd
• Allele Name: targeted mutation 1.1, Robert B Darnell
• Allele ID: MGI:5431214
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptbp2^tm1.1Rbd/Ptbp2^tm1.1Rbd	Not Specified	MGI:5431215

Genotype
MGI:5431215

hm1

• Allelic Composition: Ptbp2^tm1.1Rbd/Ptbp2^tm1.1Rbd
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:185949 )

• die soon after birth or within 10?15 min of delivery by cesarean section at embryonic day 18.5

nervous system

abnormal neuron differentiation ( J:185949 )

• abnormal neural stem cell polarity

premature neuronal precursor differentiation ( J:185949 )

• premature neurogenesis

abnormal cortical ventricular zone morphology ( J:185949 )

• mislocalization of S-phase cells with small ectopic clusters of proliferating cells in the lateral wall of the ventricular zone

decreased neuronal precursor cell number ( J:185949 )

cellular

abnormal neuron differentiation ( J:185949 )

• abnormal neural stem cell polarity

premature neuronal precursor differentiation ( J:185949 )

• premature neurogenesis