About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grin1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5431094
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5485189
cn2
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Tg(Slc6a4-cre)ET127Gsat/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:5485188
cn3
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5485191
cn4
 		Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Tg(Slc6a4-cre)ET127Gsat/0 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:5485190


Genotype
MGI:5485189
cn1
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (64 available)
Grin1tm2.1Stl mutation (0 available); any Grin1 mutation (64 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:193625 )
• disruption of somatic innervation during development in the absence of NMDARs at P14




Genotype
MGI:5485188
cn2
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (64 available)
Grin1tm2.1Stl mutation (0 available); any Grin1 mutation (64 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased excitatory postsynaptic current amplitude ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
abnormal NMDA-mediated synaptic currents ( J:193625 )
• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
reduced NMDA-mediated synaptic currents ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
abnormal miniature excitatory postsynaptic currents ( J:193625 )
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13




Genotype
MGI:5485191
cn3
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (64 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal innervation ( J:193625 )
• disruption of somatic innervation during development in the absence of NMDARs at P14




Genotype
MGI:5485190
cn4
Allelic
Composition		 Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Tg(Slc6a4-cre)ET127Gsat/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Cell Lines EPD0469_5_C11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1c(EUCOMM)Wtsi mutation (1 available); any Grin1 mutation (64 available)
Tg(Slc6a4-cre)ET127Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased excitatory postsynaptic current amplitude ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
• however, EPSCs from principal trigeminal nucleus are normal
abnormal NMDA-mediated synaptic currents ( J:193625 )
• at P13 to P14, deletion of NMDARs disrupts elimination of redundant inputs, synaptic strengthening and pruning of somatic innervation compared to in wild-type mice
• however, EPSCs from principal trigeminal nucleus are normal
reduced NMDA-mediated synaptic currents ( J:193625 )
• very small or no NMDAR excitatory postsynaptic currents at P10 and P13 to P14 in some ventral posteromedial nucleus neurons
abnormal miniature excitatory postsynaptic currents ( J:193625 )
• reduced frequency, amplitude and decay constant in the absence of NMDAR at P13




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory