About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pax6-HRAS*G12V)2044Ove
transgene insertion 2044, Paul A Overbeek
MGI:5430364
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Pax6-HRAS*G12V)2044Ove/0 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N MGI:5430384
tg2
 		Tg(Pax6-HRAS*G12V)2044Ove/0 involves: FVB/N MGI:5430365


Genotype
MGI:5430384
cn1
Allelic
Composition		 Ugdhtm1.1Xzh/Ugdhtm1.1Xzh
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Pax6-HRAS*G12V)2044Ove/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Tg(Pax6-HRAS*G12V)2044Ove mutation (0 available)
Ugdhtm1.1Xzh mutation (1 available); any Ugdh mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:185652 )
N
• robust lacrimal gland budding is seen unlike in mutant mice lacking Tg(Pax6-HRAS*G12V)2044Ove




Genotype
MGI:5430365
tg2
Allelic
Composition		 Tg(Pax6-HRAS*G12V)2044Ove/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Altered lens and corneal development inTg(Pax6-HRAS*G12V)2044Ove/0 mice

vision/eye
abnormal cornea epithelium morphology ( J:158529 )
• in the central cornea at E18.5
abnormal cornea stroma morphology ( J:158529 )
• in the central cornea at E18.5
abnormal eye development ( J:158529 )
• extra cells extending into the interior of the lens pit are seen at E10.5
• at E11.5, lenses and corneas display epithelial hyperplasia
• increase in proliferation of lens and corneal epithelial cells at E11.5 and E13.5
• expression analysis indicates abnormal differentiation of the cornea
abnormal lens development ( J:158529 )
• extra cells seen in the lens pit are internalized within the lumen of the lens at E11.5
• at E16.5 the lens epithelial show an elongated rather than cuboidal morphology
• expression analysis indicates abnormal differentiation of the lens
fused cornea and lens ( J:158529 )
• at E13.5 the lens is embedded in the cornea
• at E16.5 the lens remains attached to the cornea
lens vacuoles ( J:158529 )
• at E18.5
failure of eyelid fusion ( J:158529 )
• remain open at E16.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory