Phenotypes associated with this allele

• Allele Symbol: Nme5^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5429195
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nme5^tm1Lex/Nme5^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429549

Genotype
MGI:5429549

hm1

• Allelic Composition: Nme5^tm1Lex/Nme5^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

nasal inflammation ( J:185566 )

• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates

maxillary sinus inflammation ( J:185566 )

• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates

cardiovascular system

intraventricular hemorrhage ( J:185566 )

• mild intraventricular hemorrhage in lateral and third ventricles

craniofacial

domed cranium ( J:185566 )

• doming of skull is evident

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • notably, situs inversus was not detected

nervous system

intraventricular hemorrhage ( J:185566 )

• mild intraventricular hemorrhage in lateral and third ventricles

hydrocephaly ( J:185566 )

• moderate to marked hydrocephalus

reproductive system

abnormal sperm flagellum morphology ( J:185566 )

♂ • limited formation of sperm tails, although normal condensation and flattening of sperm heads is seen

detached sperm flagellum ( J:185566 )

♂ • reduced formation of sperm flagella, most of which are detached

azoospermia ( J:185566 )

♂ • aspermia is evident in all middle and distal epididymal tubules

abnormal spermatid morphology ( J:185566 )

♂ • degeneration of late stage spermatids

arrest of spermatogenesis ( J:185566 )

♂ • in 6 week old male mice, late stage spermatogonic arrest and degeneration is seen

respiratory system

nasal inflammation ( J:185566 )

• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates

maxillary sinus inflammation ( J:185566 )

• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates

impaired mucociliary clearance ( J:185566 )

skeleton

domed cranium ( J:185566 )

• doming of skull is evident

cellular

abnormal sperm flagellum morphology ( J:185566 )

♂ • limited formation of sperm tails, although normal condensation and flattening of sperm heads is seen

detached sperm flagellum ( J:185566 )

♂ • reduced formation of sperm flagella, most of which are detached

azoospermia ( J:185566 )

♂ • aspermia is evident in all middle and distal epididymal tubules

abnormal spermatid morphology ( J:185566 )

♂ • degeneration of late stage spermatids

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566