Phenotypes associated with this allele

• Allele Symbol: Nuak1^tm1Esu
• Allele Name: targeted mutation 1, Hiroyasu Esumi
• Allele ID: MGI:5428915
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nuak1^tm1Esu/Nuak1^tm1Esu Tg(Ckmm-cre)5Khn/0	B6.Cg-Nuak1^tm1Esu Tg(Ckmm-cre)5Khn	MGI:5428916

Genotype
MGI:5428916

cn1

• Allelic Composition: Nuak1^tm1Esu/Nuak1^tm1Esu; Tg(Ckmm-cre)5Khn/0
• Genetic Background: B6.Cg-Nuak1^tm1Esu Tg(Ckmm-cre)5Khn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:185463 )

N • no differences are detected in heart or soleus muscle weights and soleus myocyte cross sections are similar to controls on both normal chow and high fat diets

abnormal muscle cell glucose uptake ( J:185463 )

• in soleus muscle cells from mice on a high fat diet glucose uptake is similar to mice on a normal chow diet unlike in wild-type mice where the high fat diet impairs glucose uptake

increased skeletal muscle glycogen level ( J:185463 )

• in mice fed a normal chow or high fat diet compared to diet matched controls

homeostasis/metabolism

decreased circulating glucose level ( J:185463 )

• in mice on a high fat diet, fasting glucose levels are reduced at 13 - 15 and 18-19 weeks of age compared to diet matched controls

• no difference in glucose levels compared to controls is detected in mice on a normal chow diet

improved glucose tolerance ( J:185463 )

• in mice on a high fat diet compared to diet matched controls

increased skeletal muscle glycogen level ( J:185463 )

• in mice fed a normal chow or high fat diet compared to diet matched controls

increased insulin sensitivity ( J:185463 )

• in mice on a high fat diet compared to diet matched controls

cellular

abnormal muscle cell glucose uptake ( J:185463 )

• in soleus muscle cells from mice on a high fat diet glucose uptake is similar to mice on a normal chow diet unlike in wild-type mice where the high fat diet impairs glucose uptake