Phenotypes associated with this allele

• Allele Symbol: Sprn^tm1Geno
• Allele Name: targeted mutation 1, Genoway
• Allele ID: MGI:5428663
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sprn^tm1Geno/Sprn^tm1Geno	involves: 129S2/SvPas * C57BL/6J	MGI:5428670
hm2	Sprn^tm1Geno/Sprn^tm1Geno	involves: 129S2/SvPas * C57BL/6J * FVB/NCr	MGI:5428671
cx3	Prnp^tm1Cwe/Prnp^tm1Cwe Sprn^tm1Geno/Sprn^tm1Geno	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:5428672

Genotype
MGI:5428670

hm1

• Allelic Composition: Sprn^tm1Geno/Sprn^tm1Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:184837 )

N • mice exhibit normal survival following prion infection

growth/size/body

decreased body weight ( J:184837 )

• in female mice between P8 and P16

increased body weight ( J:184837 )

• in male mice between P28 and P42

Genotype
MGI:5428671

hm2

• Allelic Composition: Sprn^tm1Geno/Sprn^tm1Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * FVB/NCr

growth/size/body

decreased body weight ( J:184837 )

• in male mice at P22

increased body weight ( J:184837 )

• in male mice between P29 and P50

Genotype
MGI:5428672

cx3

• Allelic Composition: Prnp^tm1Cwe/Prnp^tm1Cwe; Sprn^tm1Geno/Sprn^tm1Geno
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

mortality/aging

mortality/aging ( J:184837 )

N • mice exhibit normal survival unlike Prnp^tm1Cwe homozygotes

behavior/neurological

limb grasping ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

tremors ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

ataxia ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

dysmetria ( J:184837 )

• as in Prnp^tm1Cwe homozygotes

nervous system

nervous system phenotype ( J:184837 )

N • unlike Prnp^tm1Cwe homozygotes, mice do not exhibit dysmyelination or granulomatous infiltration in the lateral horns of the spinal cord