Phenotypes associated with this allele

• Allele Symbol: Tg(Col1a1-Mir34c)#Kry
• Allele Name: transgene insertion, Gerard Karsenty
• Allele ID: MGI:5427917
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Col1a1-Mir34c)#Kry/0	B6.Cg-Tg(Col1a1-Mir34c)#Kry	MGI:5427923

Genotype
MGI:5427923

tg1

• Allelic Composition: Tg(Col1a1-Mir34c)#Kry/0
• Genetic Background: B6.Cg-Tg(Col1a1-Mir34c)#Kry

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased bone mass in Tg(Col1a1-Mir34c)#Kry/0 mice

cellular

abnormal osteoblast physiology ( J:185130 )

• decreased osteoblast activity

decreased osteoblast proliferation ( J:185130 )

• decreased osteoblast proliferation compared with controls

skeleton

skeleton phenotype ( J:185130 )

N • osteoclast surface and bone resorption are normal

abnormal osteoblast physiology ( J:185130 )

• decreased osteoblast activity

decreased osteoblast proliferation ( J:185130 )

• decreased osteoblast proliferation compared with controls

decreased osteoblast cell number ( J:185130 )

decreased bone mass ( J:185130 )

abnormal skeleton development ( J:185130 )

• decreased bone formation rate