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| Caption | Overexpessing Mir34c in osteoblasts specifically decreased bone mass. (B) Bone histomorphometric analysis of L3 and L4 vertebrae of 3-month-old transgenic Tg(Col1a1-Mir34c)#Kry/0 (alpha1(l)-miR-34c) mice (n = 5-9). Mineralized bone volume over the total tissue volume (BV/TV), as revealed by Von Kossa/Von Gesien staining; mineralized tissues were stained black and nonmineralized tissues were stained red. Osteoblast number per tissue area (N.Ob/T.Ar), as revealed by toluidine blue staining and osteoblasts (arrowarrowheads), were identified as plump, cuboidal cells with a perinuclear clear zone on bone surfaces); the annual fractional volume of trabecular bone formed per unit trabecular surface area (BFR/BS) was calculated from the extent of bone surface labeled with calcein (fluorescent green labels) and the distance between the labels in areas where two labels are present. Osteoclast surface per bone surface (Oc.S/BS), as measured by TRAP staining; osteoclasts were identified as red staining cells on the bone surface. Bars, 20 um. | ||||
| Copyright | This image is from Wei J, J Cell Biol 2012 May 14;197(4):509-21, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:185130 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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