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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax2tm1Gdr
targeted mutation 1, Gregory R Dressler
MGI:5427893
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax2tm1Gdr/Pax2tm1Gdr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5427898
ht2
 		Pax2tm1Gdr/Pax2tm1.1Gdr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5427900


Genotype
MGI:5427898
hm1
Allelic
Composition		 Pax2tm1Gdr/Pax2tm1Gdr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax2tm1Gdr mutation (1 available); any Pax2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney medulla cyst ( J:184878 )
• in some mice
abnormal kidney lobule morphology ( J:184878 )
• lobular kidneys in some mice
renal hypoplasia ( J:184878 )
• unilaterally in some mice
• in mice without congenital kidney abnormalities
decreased nephron number ( J:184878 )
• in mice without congenital kidney abnormalities
double ureter ( J:184878 )
• in some mice

growth/size/body
kidney medulla cyst ( J:184878 )
• in some mice




Genotype
MGI:5427900
ht2
Allelic
Composition		 Pax2tm1Gdr/Pax2tm1.1Gdr
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax2tm1.1Gdr mutation (1 available); any Pax2 mutation (47 available)
Pax2tm1Gdr mutation (1 available); any Pax2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
abnormal kidney development ( J:184878 )
• mice have very rudimentary kidneys at birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory