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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrbp1tm1.2Dja
targeted mutation 1.2, David J Adams
MGI:5427570
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrbp1tm1.2Dja/Nrbp1tm1.2Dja involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:5427572
cn2
 		Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J MGI:5427573
cn3
 		Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:5427571


Genotype
MGI:5427572
hm1
Allelic
Composition		 Nrbp1tm1.2Dja/Nrbp1tm1.2Dja
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrbp1tm1.2Dja mutation (0 available); any Nrbp1 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5427573
cn2
Allelic
Composition		 Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Nrbp1tm1.1Dja mutation (0 available); any Nrbp1 mutation (52 available)
Nrbp1tm1.2Dja mutation (0 available); any Nrbp1 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
increased lung carcinoma incidence ( J:184685 )
• in tamoxifen-treated mice

mortality/aging
decreased tumor-free survival time ( J:184685 )
• moribund as early as 3 days post tamoxifen treatment
• 75% of mice die 9 days after tamoxifen treatment
• mice treated with a low dose of tamoxifen exhibit increased death associated with tumorigenesis

digestive/alimentary system
abnormal enterocyte proliferation ( J:184685 )
• tamoxifen-treated mice exhibit increased cell proliferation in the intestinal epithelium compared with control mice
abnormal intestine morphology ( J:184685 )
• loss of architecture in tamoxifen-treated mice with reduction in numbers of differentiated cells, cells showing dysplastic nuclear atypia, widespread crypt elongation, increased crypt fission and reduction in villous length
abnormal intestinal mucosa morphology ( J:184685 )
• in tamoxifen-treated mice
abnormal intestinal goblet cell morphology ( J:184685 )
• tamoxifen-treated mice exhibit a decrease of Alcian Blue positive goblet cells compared with control mice
abnormal intestinal enteroendocrine cell morphology ( J:184685 )
• reduced numbers in tamoxifen-treated mice
abnormal crypts of Lieberkuhn morphology ( J:184685 )
• elongated in tamoxifen-treated mice
ectopic Paneth cells ( J:184685 )
• altered distribution in tamoxifen-treated mice
intestinal edema ( J:184685 )
• in tamoxifen-treated mice
distended stomach ( J:184685 )
• in tamoxifen-treated mice
increased gastrointestinal tumor incidence ( J:184685 )
• in 6 of 16 tamoxifen-treated mice, 2 of which are adenomas with high-grade dysplasia and 2 are invasive adenocarcinoma
• 5 of 6 tumors are located in the caecum

neoplasm
increased tumor incidence ( J:184685 )
• tamoxifen-treated mice exhibit increased incidence of tumorigenesis, including lymphomas/leukemias and solid tumors (angiosarcoma, gastrointestinal adenoma, gastrointestinal adenocarcinoma and lung carcinoma)
increased gastrointestinal tumor incidence ( J:184685 )
• in 6 of 16 tamoxifen-treated mice, 2 of which are adenomas with high-grade dysplasia and 2 are invasive adenocarcinoma
• 5 of 6 tumors are located in the caecum
increased leukemia incidence ( J:184685 )
• in tamoxifen-treated mice
increased lymphoma incidence ( J:184685 )
• in tamoxifen-treated mice
increased lung carcinoma incidence ( J:184685 )
• in tamoxifen-treated mice

liver/biliary system
abnormal liver morphology ( J:184685 )
• tamoxifen-treated mice exhibit zone 3 hydropic changes indicative of malnutrition unlike control mice

homeostasis/metabolism
intestinal edema ( J:184685 )
• in tamoxifen-treated mice

cellular
abnormal intestinal goblet cell morphology ( J:184685 )
• tamoxifen-treated mice exhibit a decrease of Alcian Blue positive goblet cells compared with control mice
abnormal enterocyte proliferation ( J:184685 )
• tamoxifen-treated mice exhibit increased cell proliferation in the intestinal epithelium compared with control mice

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:184685 )
• elongated in tamoxifen-treated mice
ectopic Paneth cells ( J:184685 )
• altered distribution in tamoxifen-treated mice




Genotype
MGI:5427571
cn3
Allelic
Composition		 Nrbp1tm1.1Dja/Nrbp1tm1.2Dja
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (57 available)
Nrbp1tm1.1Dja mutation (0 available); any Nrbp1 mutation (52 available)
Nrbp1tm1.2Dja mutation (0 available); any Nrbp1 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine morphology ( J:184685 )
• authors state that tamoxifen-treated mice exhibit similar phenotype as Nrbp1tm1.1Dja/Nrbp1tm1.1Dja Gt(ROSA)26Sortm1(cre/ERT)Brn/ Gt(ROSA)26Sor+ mice
abnormal intestinal goblet cell morphology ( J:184685 )
• abnormal goblet cell production in tamoxifen-treated mice
abnormal Paneth cell morphology ( J:184685 )
• abnormal granularization of Paneth cells in tamoxifen-treated mice
ectopic Paneth cells ( J:184685 )
• abnormal localization of Paneth cells in tamoxifen-treated mice

endocrine/exocrine glands
abnormal Paneth cell morphology ( J:184685 )
• abnormal granularization of Paneth cells in tamoxifen-treated mice
ectopic Paneth cells ( J:184685 )
• abnormal localization of Paneth cells in tamoxifen-treated mice

cellular
abnormal intestinal goblet cell morphology ( J:184685 )
• abnormal goblet cell production in tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory