Phenotypes associated with this allele

• Allele Symbol: Fgf21^tm1Fdl
• Allele Name: targeted mutation 1, Francesco De Luca
• Allele ID: MGI:5427438
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf21^tm1Fdl/Fgf21^tm1Fdl	B6.Cg-Fgf21^tm1Fdl	MGI:5427439

Genotype
MGI:5427439

hm1

• Allelic Composition: Fgf21^tm1Fdl/Fgf21^tm1Fdl
• Genetic Background: B6.Cg-Fgf21^tm1Fdl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:184999 )

• 6 times in food restricted mice

decreased circulating growth hormone level ( J:184999 )

• in food restricted mice treated with human recombinant Fgf21

increased circulating growth hormone level ( J:184999 )

• 2 to 3 times in food restricted mice

skeleton

long tibia ( J:184999 )

• food restricted mice are partially spared from reduction in tibia length

• however, treatment with human recombinant Fgf21 restores normal phenotype

increased width of hypertrophic chondrocyte zone ( J:184999 )

• in food restricted mice

increased long bone epiphyseal plate size ( J:184999 )

• food restricted mice are partially spared from reduction in tibia growth plate thickness

growth/size/body

increased body length ( J:184999 )

• food restricted mice are partially spared from reduction in body length

• however, treatment with human recombinant Fgf21 restores normal phenotype

limbs/digits/tail

long tibia ( J:184999 )

• food restricted mice are partially spared from reduction in tibia length

• however, treatment with human recombinant Fgf21 restores normal phenotype