Phenotypes associated with this allele

• Allele Symbol: Pnpla2^tm1Gam
• Allele Name: targeted mutation 1, Grant A Mitchell
• Allele ID: MGI:5427437
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pnpla2^tm1Gam/Pnpla2^tm1Gam Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA	MGI:5427456

Genotype
MGI:5427456

cn1

• Allelic Composition: Pnpla2^tm1Gam/Pnpla2^tm1Gam; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased liver weight ( J:185116 )

• at 3 months

homeostasis/metabolism

decreased fatty acid oxidation ( J:185116 )

• decreased fatty acid oxidation in the liver

increased circulating free fatty acids level ( J:185116 )

• after 48 hours of fasting

increased circulating alanine transaminase level ( J:185116 )

• without a change in macrophage numbers, fibrosis or apoptosis

increased liver triglyceride level ( J:185116 )

• at 3 months

decreased basal metabolism ( J:185116 )

• heat production after 48 hours of fasting is lower than in wild-type mice

liver/biliary system

abnormal cholangiocyte morphology ( J:185116 )

• cholangiocytes contain lipid droplets unlike in wild-type mice

increased liver weight ( J:185116 )

• at 3 months

increased liver triglyceride level ( J:185116 )

• at 3 months

abnormal hepatocyte morphology ( J:185116 )

• increase in size and number of hepatocyte lipid droplets

• increased lipolysosomes

macrovesicular hepatic steatosis ( J:185116 )

• progressive macrovesicular steatosis

microvesicular hepatic steatosis ( J:185116 )

• pericentral microvesicular steatosis

cellular

decreased fatty acid oxidation ( J:185116 )

• decreased fatty acid oxidation in the liver

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:185116 )

• cholangiocytes contain lipid droplets unlike in wild-type mice