All Phenotypes Oma1<tm1Otin> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oma1^tm1Otin/Oma1^tm1Otin	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr	MGI:5426691
cx2	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1^tm1Otin	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	MGI:7579309
cx3	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	MGI:7579310

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased fatty acid beta-oxidation ( J:184716 )

• mice fed standard chow exhibit decreased fatty acid beta-oxidation in brown adipose tissue compared with wild-type mice

• mice fed a high fat diet exhibit decreased fatty acid beta-oxidation in brown adipose tissue and liver compared with wild-type mice

increased susceptibility to diet-induced obesity ( J:184716 )

• at 8 weeks when fed a high fat diet

abnormal blood homeostasis ( J:184716 )

increased circulating leptin level ( J:184716 )

• when fed a high fat diet

increased circulating triglyceride level ( J:184716 )

• when fed a high fat diet

increased circulating alanine transaminase level ( J:184716 )

• when fed a high fat diet

increased circulating aspartate transaminase level ( J:184716 )

• when fed a high fat diet

decreased body temperature ( J:184716 )

• when cold exposed

abnormal circadian temperature homeostasis ( J:184716 )

• mice fed standard chow fail to exhibit an increase in body temperature during the night unlike wild-type mice

abnormal gas homeostasis ( J:184716 )

decreased carbon dioxide production ( J:184716 )

• when fed standard chow

decreased oxygen consumption ( J:184716 )

• when fed standard chow

abnormal glucose homeostasis ( J:184716 )

decreased circulating insulin level ( J:184716 )

• when fed standard chow

impaired glucose tolerance ( J:184716 )

• when fed a high fat diet

increased insulin sensitivity ( J:184716 )

• when fed standard chow but not a high fat diet

decreased basal metabolism ( J:184716 )

• mice fed standard chow exhibit decreased heat production compared with control mice

cellular

abnormal mitochondrial morphology ( J:184716 )

• prior to and after treatment with CCCP, mouse embryonic fibroblasts exhibit alterations in mitochondria morphology with lower fragmentation compared with wild-type cells

• mitochondria of brown adipose tissue from cold-exposed mice fed a high fat diet fail to exhibit an increase in mitochondria area unlike wild-type mice

• however, mice do not exhibit a change in the number of mitochondria

decreased mitochondrial DNA content ( J:184716 )

• in mouse embryonic fibroblasts

increased mitochondrial size ( J:184716 )

• in brown adipose tissue of mice fed a high fat diet

abnormal cell physiology ( J:184716 )

• mouse embryonic fibroblasts treated with CCCP, straurosporine or oligomycin exhibit altered OPA1 processing compared with wild-type cells

decreased cellular sensitivity to alkylating agents ( J:184716 )

• in straurosporine treated mouse embryonic fibroblasts

decreased fatty acid beta-oxidation ( J:184716 )

• mice fed standard chow exhibit decreased fatty acid beta-oxidation in brown adipose tissue compared with wild-type mice

• mice fed a high fat diet exhibit decreased fatty acid beta-oxidation in brown adipose tissue and liver compared with wild-type mice

adipose tissue

increased white fat cell size ( J:184716 )

• in gonadal and subcutaneous fat pads when mice are fed a high fat diet

increased gonadal fat pad weight ( J:184716 )

• when fed a high fat diet

abnormal mesenteric fat pad morphology ( J:184716 )

• granuloma-like lesions with necrosis foci in intestinal mesenteric fat when mice are fed a high fat diet

abnormal brown adipose tissue thermogenesis ( J:184716 )

• cold-exposed mice fail to exhibit a decrease in brown adipose tissue droplet size unlike wild-type mice

growth/size/body

increased body weight ( J:184716 )

• when fed standard chow

• at 8 weeks when fed a high fat diet

increased susceptibility to diet-induced obesity ( J:184716 )

• at 8 weeks when fed a high fat diet

liver/biliary system

hepatic steatosis ( J:184716 )

• when fed standard chow or a high fat diet

immune system

granulomatous inflammation ( J:184716 )

• granuloma-like lesions with necrosis foci in intestinal mesenteric fat when mice are fed a high fat diet

Allelic Composition	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1^tm1Otin
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chchd10^em3Dpn mutation (0 available); any Chchd10 mutation (16 available)
Oma1^tm1Otin mutation (0 available); any Oma1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:344465 )

• neonatal lethality with few mice surviving to weaning

postnatal lethality, incomplete penetrance ( J:344465 )

• most pups die between P5 and P8, with the few survivors dying by 15 weeks of age

growth/size/body

enlarged heart ( J:344465 )

• mice that survive to 15 weeks of age have enlarged hearts

decreased body size ( J:344465 )

• mice that survive to 15 weeks of age exhibit decreased body size

decreased body weight ( J:344465 )

• body weight is lower at P5 but not at P1

cardiovascular system

enlarged heart ( J:344465 )

• mice that survive to 15 weeks of age have enlarged hearts

cellular

abnormal mitochondrial crista morphology ( J:344465 )

• heart mitochondria exhibit inclusions

abnormal mitochondrial shape ( J:344465 )

• surviving mice exhibit heart mitochondria that are longer but tend to have decreased caliber and thus smaller in volume

dilated mitochondrion ( J:344465 )

• megamitochondria, massively swollen mitochondria with lighter matrix density, are seen in hearts of 14-week-old mice

Allelic Composition	Chchd10^em3Dpn/Chchd10^em3Dpn Oma1^tm1Otin/Oma1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle fiber mitochondrial morphology ( J:344465 )

• hearts show mitochondrial fragmentation, megamitochondria, and inclusions due to reshaping of the inner membrane

cellular

abnormal mitochondrial morphology ( J:344465 )

• mice exhibit smaller heart mitochondria, reflecting mitochondrial fragmentation

abnormal mitochondrial crista morphology ( J:344465 )

• heart mitochondria exhibit inclusions due to reshaping of the inner membrane

abnormal muscle fiber mitochondrial morphology ( J:344465 )

• hearts show mitochondrial fragmentation, megamitochondria, and inclusions due to reshaping of the inner membrane

dilated mitochondrion ( J:344465 )

• megamitochondria, massively swollen mitochondria with lighter matrix density, are seen in hearts of 14-week-old mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23