Phenotypes associated with this allele

• Allele Symbol: Nxnl2^tm1.2Tlev
• Allele Name: targeted mutation 1.2, Thierry Leveillard
• Allele ID: MGI:5426260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nxnl2^tm1.2Tlev/Nxnl2^tm1.2Tlev	BALB/c-Nxnl2^tm1.2Tlev	MGI:5426266

Genotype
MGI:5426266

hm1

• Allelic Composition: Nxnl2^tm1.2Tlev/Nxnl2^tm1.2Tlev
• Genetic Background: BALB/c-Nxnl2^tm1.2Tlev

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased retina cone cell number ( J:183790 )

• reduced S- and M-cone densities at 10 months

short photoreceptor outer segment ( J:183790 )

• at 10 months

abnormal cone electrophysiology ( J:183790 )

• at 10 months, mice exhibit reduced photopic electroretinogram of b-wave amplitude compared with wild-type mice

• however, expression of the short trophic isoform rescues cone electrophysiology

abnormal rod electrophysiology ( J:183790 )

• at 10 months, mice exhibit decreased a-wave amplitudes compared with wild-type mice

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:183790 )

• reduced survival

impaired olfaction ( J:183790 )

• impaired olfactory discrimination with age

nervous system

abnormal olfactory sensory neuron morphology ( J:183790 )

• reduced survival

decreased retina cone cell number ( J:183790 )

• reduced S- and M-cone densities at 10 months

short photoreceptor outer segment ( J:183790 )

• at 10 months

craniofacial

abnormal olfactory sensory neuron morphology ( J:183790 )

• reduced survival

respiratory system

abnormal olfactory sensory neuron morphology ( J:183790 )

• reduced survival

growth/size/body

abnormal olfactory sensory neuron morphology ( J:183790 )

• reduced survival