Phenotypes associated with this allele

• Allele Symbol: Car5a^tm1Sly
• Allele Name: targeted mutation 1, William S Sly
• Allele ID: MGI:5425618
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Car5a^tm1Sly/Car5a^tm1Sly	involves: 129X1/SvJ * C57BL/6	MGI:5515769
cx2	Car5a^tm1Sly/Car5a^tm1Sly Car5b^tm1Sly/Car5b^tm1Sly	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5515773
cx3	Car5a^tm1Sly/Car5a^tm1Sly Car5b^tm1Sly/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5515774

Genotype
MGI:5515769

hm1

• Allelic Composition: Car5a^tm1Sly/Car5a^tm1Sly
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:196135 )

• both males and females are smaller than controls

mortality/aging

mortality/aging ( J:196135 )

N • normal survival

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196135 )

N • blood glucose levels are like controls both when fed and while fasting

abnormal homeostasis ( J:196135 )

• elevated levels of alpha-ketoglutarate, fumarate, malate, acetoacetate, subaric acid, and sebacic acid

increased circulating ammonia level ( J:196135 )

• significantly elevated

Genotype
MGI:5515773

cx2

• Allelic Composition: Car5a^tm1Sly/Car5a^tm1Sly; Car5b^tm1Sly/Car5b^tm1Sly
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

growth/size/body

decreased body size ( J:196135 )

♀ • females are significantly smaller than controls

mortality/aging

premature death ( J:196135 )

♀ • die prematurely beginning shortly after weaning

preweaning lethality, incomplete penetrance ( J:196135 )

♀ • 11 females compared to 17 for controls

homeostasis/metabolism

increased circulating ammonia level ( J:196135 )

♀ • significantly elevated, higher than in Car5a^tm1Sly homozygotes

decreased circulating glucose level ( J:196135 )

♀ • fasting blood sugar is significantly lower than in controls

♀ • blood sugar is similar to controls when fed

cellular

oxidative stress ( J:181790 )

♀ • reduced oxidative stress in the brain

♀ • elevated levels of glutathione

♀ • reduced SOD, HNE, and 3-NT

Genotype
MGI:5515774

cx3

• Allelic Composition: Car5a^tm1Sly/Car5a^tm1Sly; Car5b^tm1Sly/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

growth/size/body

decreased body size ( J:196135 )

♂ • males are significantly smaller than controls

mortality/aging

premature death ( J:196135 )

♂ • die prematurely beginning shortly after weaning

♂ • males die more rapidly than females

preweaning lethality, incomplete penetrance ( J:196135 )

♂ • 38 males compared to 84 for controls

homeostasis/metabolism

increased circulating ammonia level ( J:196135 )

♂ • significantly elevated, higher than in Car5a^tm1Sly homozygotes

decreased circulating glucose level ( J:196135 )

♂ • fasting blood sugar is significantly lower than in controls

♂ • blood sugar is similar to controls when fed

cellular

oxidative stress ( J:181790 )

♂ • reduced oxidative stress in the brain

♂ • elevated levels of glutathione

♂ • reduced SOD, HNE, and 3-NT