homeostasis/metabolism
endocrine/exocrine glands
|
• mice exhibit hyperparathyroidism
|
immune system
|
• C-reactive protein in plasma is lower
|
liver/biliary system
N |
• no liver inflammation is seen
|
renal/urinary system
N |
• mice exhibit normal glomerular filtration rate, plasma urea and creatinine levels, and urea clearance, and no nephrocalcinosis, indicating normal kidney function
|
|
• increase in urine creatinine levels
|
|
• mice show a tendency to hypocalciuria
• however, mice are normophosphatauric
|
|
• mice excrete less urine
|
skeleton
|
• lower cortical bone mineral density
|
cardiovascular system
N |
• mice exhibit normal cholesterol and high-density lipoprotein cholesterol levels in blood, normal cardiac function and left ventricle wall thickness, no calcifications in the aorta, and no indication of left ventricular hypertrophy, cardiac fibrosis, or cardiac inflammation, indicating no cardiovascular disease
|
|
• mice exhibit lower systolic blood pressure
|