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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc21tm1.1Aven
targeted mutation 1.1, Andrea Ventura
MGI:5320799
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc21tm1.1Aven/Mirc21tm1.1Aven involves: 129S4/SvJae * C57BL/6 * SJL MGI:5320803
cx2
 		Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Tg(Hlxb9-GFP)1Tmj/0 		involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:6696405
cx3
 		Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:6696404
cx4
 		Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch 		involves: 129S4/SvJae * C57BL/6J MGI:6696403


Genotype
MGI:5320803
hm1
Allelic
Composition		 Mirc21tm1.1Aven/Mirc21tm1.1Aven
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc21tm1.1Aven mutation (1 available); any Mirc21 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:184359 )
• mice are viable, fertile and normal in size




Genotype
MGI:6696405
cx2
Allelic
Composition		 Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Aven mutation (0 available); any Mir34a mutation (12 available)
Mirc21tm1.1Aven mutation (1 available); any Mirc21 mutation (5 available)
Mirc34em1Jnch mutation (0 available); any Mirc34 mutation (2 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:304721 )
N
• mice exhibit normal motor neuron development




Genotype
MGI:6696404
cx3
Allelic
Composition		 Mir34atm1.1Aven/Mir34atm1.1Aven
Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Aven mutation (0 available); any Mir34a mutation (12 available)
Mirc21tm1.1Aven mutation (1 available); any Mirc21 mutation (5 available)
Mirc34em1Jnch mutation (0 available); any Mirc34 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:304721 )
• lethality occurs between P21 to P28 in some mice
postnatal lethality, incomplete penetrance ( J:304721 )
• lethality occurs between P7 and P14

behavior/neurological
jumpy ( J:304721 )
• in home cages and open arena
abnormal locomotor coordination ( J:304721 )
• uncoordinated hind tiptoe walking
decreased locomotor activity ( J:304721 )
• slight
• however, mice exhibit normal locomotor coordination running speed, temporal composition during the step cycle, and inter-limb coordination

nervous system
nervous system phenotype ( J:304721 )
N
• mice exhibit normal motor neuron numbers
abnormal motor neuron morphology ( J:304721 )
• mice exhibit altered number of sub-population of motor synergy encoder neurons compared with wild-type mice

growth/size/body
decreased body weight ( J:304721 )
postnatal growth retardation ( J:304721 )

vision/eye




Genotype
MGI:6696403
cx4
Allelic
Composition		 Mirc21tm1.1Aven/Mirc21tm1.1Aven
Mirc34em1Jnch/Mirc34em1Jnch
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc21tm1.1Aven mutation (1 available); any Mirc21 mutation (5 available)
Mirc34em1Jnch mutation (0 available); any Mirc34 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:304721 )
• lethality occurs between P21 to P28 in some mice
postnatal lethality, incomplete penetrance ( J:304721 )
• lethality occurs between P7 and P14

behavior/neurological
jumpy ( J:304721 )
• in home cages and open arena
abnormal locomotor coordination ( J:304721 )
• uncoordinated hind tiptoe walking
decreased locomotor activity ( J:304721 )
• slight
• however, mice exhibit normal locomotor coordination running speed, temporal composition during the step cycle, and inter-limb coordination

vision/eye

growth/size/body
decreased body weight ( J:304721 )
postnatal growth retardation ( J:304721 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory