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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hk2tm1.1Uku
targeted mutation 1.1, University of Kuopio
MGI:5320615
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hk2tm1.1Uku/Hk2tm1.1Uku B6.129P2-Hk2tm1.1Uku/Kctt MGI:5432256
cn2
 		Hk2tm1.1Uku/Hk2tm1.1Uku
Tg(GFAP-cre)25Mes/0 		B6.Cg-Hk2tm1.1Uku Tg(GFAP-cre)25Mes MGI:5571382
cn3
 		Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Hk2tm1.1Uku/Hk2tm1.1Uku
Tg(GFAP-cre)25Mes/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N MGI:5571383
cn4
 		Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Hk2tm1.1Uku/Hk2+
Tg(GFAP-cre)25Mes/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N MGI:5571384


Genotype
MGI:5432256
hm1
Allelic
Composition		 Hk2tm1.1Uku/Hk2tm1.1Uku
Genetic
Background		 B6.129P2-Hk2tm1.1Uku/Kctt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hk2tm1.1Uku mutation (1 available); any Hk2 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82809 )
• no defects observed without cre-recombinase activity




Genotype
MGI:5571382
cn2
Allelic
Composition		 Hk2tm1.1Uku/Hk2tm1.1Uku
Tg(GFAP-cre)25Mes/0
Genetic
Background		 B6.Cg-Hk2tm1.1Uku Tg(GFAP-cre)25Mes
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hk2tm1.1Uku mutation (1 available); any Hk2 mutation (59 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule cell migration ( J:210113 )
• cerebellar granule neuron progenitors fail to migrate over the Purkinje cell layer
abnormal neuronal precursor proliferation ( J:210113 )
• at P7, cerebellar granule neuron progenitors exhibit reduced proliferation in response to Shh compared with wild-type cells
abnormal cerebellum external granule cell layer morphology ( J:210113 )
• focal disorganization of the external granule cell layer
• regions of focal thinning or thickening, abnormal migration and increased vascularization at P7
irregular external granule cell layer thickness ( J:210113 )
• regions of focal thinning or thickening at P7

cellular
abnormal cerebellar granule cell migration ( J:210113 )
• cerebellar granule neuron progenitors fail to migrate over the Purkinje cell layer
abnormal neuronal precursor proliferation ( J:210113 )
• at P7, cerebellar granule neuron progenitors exhibit reduced proliferation in response to Shh compared with wild-type cells




Genotype
MGI:5571383
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Hk2tm1.1Uku/Hk2tm1.1Uku
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Hk2tm1.1Uku mutation (1 available); any Hk2 mutation (59 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:210113 )
• median survival is 31 days compared with mice with wild-type Hk2 that die by P20

neoplasm
abnormal tumor vascularization ( J:210113 )
• increased micro-vascularization
decreased tumor growth/size ( J:210113 )
• compared to in mice with wild-type Hk2
increased medulloblastoma incidence ( J:210113 )
• all mice develop tumors with reduced growth and at increased latency compared to in mice with wild-type Hk2
increased tumor latency ( J:210113 )
• all mice develop tumors with increased latency compared to in mice with wild-type Hk2

nervous system
abnormal neuronal precursor proliferation ( J:210113 )
• reduced cerebellar granule neuron progenitors proliferation
increased medulloblastoma incidence ( J:210113 )
• all mice develop tumors with reduced growth and at increased latency compared to in mice with wild-type Hk2

cellular
abnormal neuronal precursor proliferation ( J:210113 )
• reduced cerebellar granule neuron progenitors proliferation

cardiovascular system
abnormal tumor vascularization ( J:210113 )
• increased micro-vascularization




Genotype
MGI:5571384
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Hk2tm1.1Uku/Hk2+
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Hk2tm1.1Uku mutation (1 available); any Hk2 mutation (59 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:210113 )
• mice die by P20

neoplasm

nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory