Phenotypes associated with this allele

• Allele Symbol: Mre11a^tm1.1Rchd
• Allele Name: targeted mutation 1.1, Stephane Richard
• Allele ID: MGI:5320419
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mre11a^tm1.1Rchd/Mre11a^tm1.1Rchd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5320420

Genotype
MGI:5320420

hm1

• Allelic Composition: Mre11a^tm1.1Rchd/Mre11a^tm1.1Rchd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:184053 )

N • mice are born in the expected Mendelian ratio

increased mortality induced by gamma-irradiation ( J:184053 )

• all irradiated mice die within 2 weeks unlike wild-type mice

reproductive system

reproductive system phenotype ( J:184053 )

N • mice are fertile

cellular

abnormal cell cycle checkpoint function ( J:184053 )

• irradiated mouse embryonic fibroblasts exhibit increased cell cycle progression due to a loss of the G2/M checkpoint compared with control cells

increased mitotic index ( J:184053 )

• in irradiated mouse embryonic fibroblasts due to a loss of the G2/M checkpoint

chromosomal instability ( J:184053 )

• irradiated mouse embryonic fibroblasts exhibit increased chromosomal abnormalities compared with wild-type cells

immune system

abnormal class switch recombination ( J:184053 )

• mice exhibit a slight reduction in class switching that is unlikely to be biologically significant

hematopoietic system

abnormal class switch recombination ( J:184053 )

• mice exhibit a slight reduction in class switching that is unlikely to be biologically significant

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:184053 )

• all irradiated mice die within 2 weeks unlike wild-type mice